Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies.
نویسندگان
چکیده
Extracts from the seed of the horse chestnut (Aesculus hippocastanum L.) have traditionally been used to treat patients with chronic venous insufficiency and to alleviate its associated symptoms, including lower leg swelling. The efficacy of preparations that contain horse chestnut seed extract (HCSE) is believed to be due largely to an inhibitory effect on the catalytic breakdown of capillary wall proteoglycans. Aesculaforce is a fresh plant HCSE that is available as an oral tincture, as tablets (20 mg or 50 mg), and as topical gel. Four clinical trials in patients with chronic venous insufficiency and 1 study in patients with varicose veins demonstrated the effectiveness of these preparations through the objective measure of reduction in lower leg edema and the subjective alleviation of leg pain, heaviness, and itching. Safe, well tolerated, and acceptable to patients, the fresh plant HCSE preparation Aesculaforce offers a real alternative in the treatment of patients with mild to moderate venous insufficiency.
منابع مشابه
Horse chestnut – efficacy and safety in chronic venous insufficiency: an overview
The extract from horse chestnut seeds (Aesculus hippocastanum L., Sapindaceae), standardised for the content of aescin, is used as the treatment for chronic venous insufficiency. It has anti-inflammatory and anti-oedematous properties and indicates a positive effect on the venous tone, rheological properties, and blood coagulability. The mechanism of horse chestnut seed extract/aescin activity ...
متن کاملReview: horse chestnut seed extract is effective for symptoms of chronic venous insufficiency.
متن کامل
Horse-chestnut (Aesculus hippocastanum) seed extract for venous leg ulceration: a comparative multiple case study of healers and non-healers
Background Venous leg ulceration (VLU) is a chronic and recurrent condition that affects around 0.12–1.1% of the Western population. One intervention that is showing promise as a treatment for VLU is horse-chestnut (Aesculus hippocastanum) seed extract (HCSE), with evidence suggesting that HCSE treatment may reduce wound slough, the frequency of dressing changes and the overall cost of VLU mana...
متن کاملCochrane Summary of Findings: Horse Chestnut Seed Extract for Chronic Venous Insufficiency
As part of its efforts to disseminate the results of Cochrane reviews to a wider audience, the Cochrane Complementary and Alternative Medicine (CAM) Field develops Summary of Findings (SoF) tables and then uses these tables as a basis for its Plain Language Summaries. In each SoF table, the most important outcomes of the review, the effect of the intervention on each outcome, and the quality of...
متن کاملEfficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies.
BACKGROUND Safe and effective oral therapies for chronic venous insufficiency (CVI) would provide an important alternative to mechanical compression treatment. Several narrative reviews and one systematic review have summarized the efficacy of horse chestnut seed extract (HCSE), but to our knowledge no systematic review has included data from both randomized controlled trials (RCTs) and large-s...
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عنوان ژورنال:
- Advances in therapy
دوره 23 1 شماره
صفحات -
تاریخ انتشار 2006